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tecovirimat will increase the level or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Tecovirimat is often a weak inhibitor of CYP2C8 and CYP2C19. Keep an eye on for adverse effects if coadministered with sensitive substrates of these enzymes.diazepam will raise the stage or effect of ruxolitinib by affecti